Benoit Driesschaert, West Virginia University
Time:
4:30 pm
Location:
Virtual seminar
Faculty host: Greg Dudley
Department of Pharmaceutical Sciences West Virginia University
Low-field electron paramagnetic resonance (EPR) with a molecular spin probe is a powerful technique to profile various biomarkers of the tissue microenvironment. Our laboratory is developing biocompatible and biostable triarylmethyl (TAM) radicals used as spin probes for in vivo EPR applications. This presentation will discuss the design, synthesis, and applications of TAM radicals sensitive to important physiological parameters such as dissolved oxygen concentration, pH, inorganic phosphate (Pi) concentration, microviscosity, and enzyme activity