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Gregory Dudley, Ph.D.

Eberly Family Distinguished Professor and Department Chair


Ph.D., Massachusetts Institute of Technology, 2000; NIH Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, 2000-2002 

Research mission: conscientiously create and disseminate knowledge in the science of synthetic organic chemistry

Research interests include natural products synthesis; new strategies, tactics, and best practices for organic chemistry; and applications of chemical synthesis to biomedical research. See for more details and full publication list.

Teaching Fields

Organic Chemistry

Representative publications

  1. Morrison, A. E.; Hrudka, J. J.; Dudley, G. B. Thermal cycloisomerization of putative allenylpyridines for the synthesis of isoquinoline derivatives. Org. Lett. 2016, 18, 4104-4107.
  2. Hoang, T. T.; Birepinte, M.; Kramer, N. J.; Dudley, G. B. Six-step synthesis of alcyopterosin A, a bioactive illudalane sesquiterpene with a gem-dimethylcyclopentane ring. Org. Lett. 2016, 18, 3470-3473. 
  3. Wright, A. K.; Batsomboon, P.; Dai, J.; Hung, I.; Zhou, H.-X.; Dudley, G. B.; Cross, T. A. Differential binding of rimantadine enantiomers to influenza A M2 proton channel. J. Am. Chem. Soc. 2016, 138, 1506-1509. 
  4. Dudley, G. B.; Richert, R.; Stiegman, A. E. On the Existence of and Mechanism for Microwave-Specific Reaction Rate Enhancement. Chem. Sci. 2015, 6, 2144-2152. 
  5. Rizkallah, R.; Batsomboon, P.; Dudley, G. B.; Hurt, M. The Oncogenic Kinase TOPK/PBK is a Master Mitotic Regulator of C2H2 Zinc Finger Proteins. Oncotarget 2015, 6, 1446-1461. 
  6. Rosana, M. R.; Hunt, J.; Ferrari, A.; Southworth, T.; Tao, Y.; Stiegman, A. E.; Dudley, G. B. Microwave-Specific Acceleration of a Friedel-Crafts Reaction: Evidence for Selective Heating in Homogeneous Solution. J. Org. Chem. 2014, 79, 7437-7450. 
  7. Hoang, T. T.; Dudley, G. B. Synthesis of high-value 1,6 enynes by tandem fragmentation / olefination. Org. Lett. 2013, 15, 4026-4029. 
  8. Lisboa, M. P.; Jones, D. M.; Dudley, G. B. Formal synthesis of palmerolide A, featuring alkynogenic fragmentation and syn-selective vinylogous aldol chemistry. Org. Lett. 2013, 15, 886-889. 
  9. Gold, B.; Dudley, G. B.; Alabugin, I. V. Moderating strain without sacrificing reactivity: Design of fast and tunable noncatalyzed alkyne-azide cycloadditions via stereoelectronically controlled transition state stabilization. J. Am. Chem. Soc. 2013, 135, 1558-1569. 
  10. Lisboa, M. P.; Hoang, T. T.; Dudley, G. B. Tandem nucleophilic addition / fragmentation of vinylogous acyl triflates: 2 methyl-2 (1 oxo-5 heptynyl)-1,3 dithiane. Org. Synth. 2011, 88, 353-363.