Glen P. Jackson, Ph.D.
Chemistry Joint Professor
Ph.D., West Virginia University
Our long-term goal is to catalyze the progress of biomedical, analytical and forensic research through the development of mass spectrometric instruments and techniques. We currently have several major projects under way:
- New ways of fragmenting gas-phase bio-ions in tandem mass spectrometers using kiloelectronvolt helium ions. We use the term charge transfer dissociation (CTD-MS) to describe the mechanism of activation. See example publications for peptides, glycosaminoglycans and HPLC-CTD-MS of oligogalacturonans.
- New forensic applications of isotope ratio mass spectrometry, including hair, nails and blow flies. We use both LC-IRMS and GC-C-IRMS to analyze the 13C abundances of the different amino acids in proteinaceous material. See example publications for hair, blowflies and oysters.
- Understanding the mass spectrometric fragmentation behavior of novel psychoactive substances (NPSs) and fentanyl analogs. See example publications for cathinones and fentalogs, including a novel rearrangement for fentalogs.
- Development of an Expert Algorithm for Substance Identification (EASI) (not yet published). This research received the 2021 FACSS Innovation Award and NIJ funding.
- Developing experimental and theoretical approaches to understand the evaporation of ignitable liquids at elevated temperatures (e.g., 210 °C). See example publication.
See all our recent publications.
- FIS 660 - Advanced Forensic Chemistry
- FIS 460/1 - Seized Drugs Analysis/Lab
- FIS 451/2 - Arson and Explosives Analysis/Lab
Publications (Most Recent)
P. M. Mendis, G. P. Jackson, “Structural Characterization of Acidic and Neutral Human Milk Oligosaccharides (HMOs) using Ultra-High Performance Liquid Chromatography-Charge Transfer Dissociation Mass Spectrometry (UHPLC-CTD-MS)" Glycobiology, 2022, cwac010. PDF View at Oxford Press.
H. M. Edwards, Z. J. Sasiene, P. M. Mendis, G. P. Jackson, “Structural Characterization of Natural and Synthetic Macrocycles using Charge Transfer Dissociation Mass Spectrometry," J. Am. Soc. Mass Spectrom, 2022, 33(4), 671-680. PDF View at ACS.
H. M. Edwards, H-T. Wu, R. R. Julian, G. P. Jackson, “Differentiating Aspartic Acid Isomers and Epimers in Peptides using Charge Transfer Dissociation Mass Spectrometry (CTD-MS),” Analyst, 2022, 147(6), 1159-1168. PDF View at RSC.
H. M. Edwards, H-T. Wu, R. R. Julian, G. P. Jackson, “Differentiation of Leucine and Isoleucine Residues in Peptides using Charge Transfer Dissociation Mass Spectrometry (CTD-MS),” Rapid Commun. Mass Spectrom., 2022, 36, e9246. PDF View at Wiley
*P. M. Mendis, Z. J. Sasiene, D. Ropartz, H. Rogniaux, G. P. Jackson, “Ultra-High Performance Liquid Chromatography Charge Transfer Dissociation Mass Spectrometry (UHPLC-CTD-MS) as a Tool for Analyzing the Structural Heterogeneity in Carrageenan Oligosaccharides,” Anal. Bioanal. Chem. (Article in Forefront; 20th Anniversary Edition), 2022, 414, 303-318. PDF View at Springer