Vicki Wysocki, Ohio State University
60th Friend E. Clark Lecture Series
John Fenn made molecular elephants fly and changed biomedical research
Phi Lambda Upsilon Honorary Chemistry Society and C. Eugene Bennett Department of Chemistry
Ohio Eminent Scholar of Macromolecular Structure and Function Department of Chemistry and Biochemistry Director, Campus Chemical Instrument Center The Ohio State University
Until the late 1980's, mass spectrometry was a useful measurement tool for measuring
relatively small molecules. With the invention of electrospray ionization, mass
spectrometry became a tool that can measure non-volatile, thermally unstable molecules
and the use of mass spectrometry as a characterization tool changed dramatically.
Today, mass spectrometry is a $6 billion industry, is used for many applications,
and new developments continue. This talk will illustrate several types of research
that have been made possible because of improvements in ionization and in mass
spectrometry instrument development. Examples will be selected from multiple fields
of research including proteomics, metabolomics/gut microbiome, and native mass
spectrometry of large protein complexes, including gene therapy platforms.