Prof. Don Watson
University of Delaware
Faculty Host: Prof. Hoover
Donald A. Watson Group Webpage
Over the past 40 years, the development of transition metal cross- coupling reactions
has primarily focused on the use of carbon electrophiles (aryl halides, vinyl
halides, and more recently alkyl halides, etc) with various nucleophilic partners.
Much less attention has been given to electrophiles of other elements in these
types of transformations. This lecture will discuss recent efforts in the Watson
group to develop hetereoatomic electrophiles for cross-coupling reactions. Specifically,
the use of electrophilic silicon, boron, and nitrogen reagents in Heck-type reactions
will be discussed. These transformations - the silyl-, boryl-, and aza-Heck reactions
- collectively provide access to high-value unsaturated organic compounds from
simple alkene starting materials. The development, scope, and mechanistic understanding
of these novel hetero-atomic. Heck reactions will be described.