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David Stuart, Portland State University

Oxidatively Generating Arynes for the Synthesis of Functionalized Arenes 

Faculty host: Brian Popp

Prof. David Stuart 

Department of Chemistry Portland State University 


Aromatic rings appear in many societally important molecules including medicines, agrochemicals, and liquid crystals. A large body of work has gone into synthetic methods to functionalize aromatic rings, especially C-H functionalization. The vast majority of methods access a limited number of arene substitution patterns and I will discuss my groups efforts to use iodonium and aryne chemistry to access other more densely functionalized arenes. This work is conducted toward our long-term goal to oxidatively generate arynes from simple and readily available aromatic building blocs.