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David Nagib, Ohio State University

C-H and C-O Functionalization viaRadical Chaperones C-H and C-O Functionalization viaRadical Chaperones

Faculty host: Jessica Hoover

Prof. David Nagib 

Department of Chemistry and Biochemistry The Ohio State University 


Our research is focused on harnessing the untapped reactivity of abundant chemical feedstocks to enable late-stage functionalization of medicinally relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols, amines, and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These radical chaperone strategies have enabled discovery of new classes of reactivity to streamline the synthesis of complex molecules with biological and industrial significance