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Benoit Driesschaert, West Virginia University

Synthesis and applications of stable triarylmethyl radicals for biomedical electron paramagnetic resonance

Faculty host: Greg Dudley

Prof. Benoit Driesschaert 

Department of Pharmaceutical Sciences West Virginia University 

Driesschaert

Low-field electron paramagnetic resonance (EPR) with a molecular spin probe is a powerful technique to profile various biomarkers of the tissue microenvironment. Our laboratory is developing biocompatible and biostable triarylmethyl (TAM) radicals used as spin probes for in vivo EPR applications. This presentation will discuss the design, synthesis, and applications of TAM radicals sensitive to important physiological parameters such as dissolved oxygen concentration, pH, inorganic phosphate (Pi) concentration, microviscosity, and enzyme activity