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Margaret Hilton, Ph.D.

Assistant Professor

Hilton Group Website


Dr. Hilton completed her PhD at the University of Utah in 2017 with Matthew Sigman, working on the optimization and mechanisms of palladium-catalyzed reactions. She joined Scott Miller’s lab at Yale University for her postdoctoral studies, studying peptide catalysts for the late stage modification of natural products.   

Dr. Hilton joined the department at WVU in 2020, and her research group focuses on developing new organic transformations and designing more efficient and selective catalysts with applications in the synthesis of drug-like molecules and an emphasis on understanding reaction mechanism.

 Recent Publications:

Hilton, M. J.; Brackett, C; Blagg, B.; Miller, S. J. “Catalysis-Enabled Access to Cryptic Geldanamycin Oxides” ACS Cent Sci. 2020, 6, 426–435.

Coelho, J. A. S.; Matsumoto, A.; Orlandi, M.; Hilton, M. J.; Sigman, M. S. Toste, F. D. “Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions” Chem. Sci. 2018, 9, 7153–7158.

Orlandi, M.; Hilton, M. J.; Yamamoto, E.; Toste, F. D.; Sigman, M. S. "Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates" J. Am. Chem. Soc. 2017, 139, 12688.

Orlandi, M.; Coelho, J. A. S.; Hilton, M. J.; Toste, F. D.; Sigman, M. S. “Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis” J. Am. Chem. Soc. 2017, 139, 6803.

Neel, A.; Hilton, M. J.; Sigman, M. S.; Toste, F. D. “Exploiting Noncovalent π Interactions for Catalyst Design” Nature 2017, 543, 637.

Hilton, M. J.; Sigman, M. S.* "(S)-4-(tert-Butyl)-2-[4-(trifluoromethyl) pyridin-2-yl]-4,5-dihydrooxazole" Encyclopedia of Reagents for Organic Synthesis; John Wiley & Sons, Ltd: 2016.

Yamamoto, E.*; Hilton, M. J.*; Orlandi, M.; Saini, V.; Toste, F. D; Sigman, M. S. “Development and Analysis of a Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Acrylates Enabled by Chiral Anion Phase-Transfer” J. Am. Chem. Soc. 2016, 138, 15877. *contributed equally

Chen, Z.-M.; Hilton, M. J.; Sigman, M. S. “Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols” J. Am. Chem. Soc. 2016, 138, 11461‒11464.

Hilton, M. J.; Cheng, B.; Buckley, B. R.; Xu, L.; Wiest, O.; Sigman, M. S.* “Relative reactivity of alkenyl alcohols in the palladium-catalyzed redox-relay Heck reaction,” Tetrahedron 2015, 71, 6513–6518.

Hilton, M. J.; Xu, L.-P.; Norrby, P.-O.; Wu, Y.-D.; Wiest, O.; Sigman, M. S. “Investigating the Nature of Palladium Chain-Walking in the Enantioselective Redox-Relay Heck Reaction of Alkenyl Alcohols,” J. Org. Chem. 2014, 79, 11841‒11850.

Xu, L.; Hilton, M. J.; Zhang, X.; Norrby, P.-O.; Wu, Y.-D.; Sigman, M.S.; Wiest, O. "Mechanism, Reactivity and Selectivity in Palladium-Catalyzed Redox-Relay Heck Arylations of Alkenyl Alcohols" J. Am. Chem. Soc. 2014, 136, 1960‒1967.