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Dr. Nickeisha Stephenson, The University of West Indies at Mona

Spirocyclic hypervalent iodine(III)=mediated radiofluorination as a practical method to synthesize fluorine-18 labeled non-activated aromatics

Faculty Host: Prof. Hoover 
UWI Chemistry Website 

Fluorine-18 labelled arenes and heteroarenes are an important class of substrates in medical imaging by positron emission tomography (PET). Traditionally, these molecules are prepared via nucleophilic aromatic substitution (SNAr) reactions of an appropriately activated substrate, which limits the scope of molecules that can be radiolabelled with [18F]fluoride. This presentation will discuss an alternative methodology that employs the use of spirocyclic hypervalent iodine(III)-complexes for the efficient one-step labelling of a broad range of non-activated functionalized arenes and heteroarenes. The application of this methodology towards preclinical and clinical research will be discussed.

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