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Jonathan Boyd, Ph.D.

Associate Professor

About

Dr. Boyd earned his B.S. degree in biochemistry in 1998 under the supervision of Dr. David Laude at the University of Texas at Austin and his Ph.D. in environmental toxicology in 2004 at Texas Tech University under the supervision of Dr. George P. Cobb III. 

Research

Dr. Boyd's graduate studies focused on the development of fieldable sensors to achieve single system passive collection and rapid detection of toxicant vapors in indoor environments. Dr. Boyd concurrently developed a technique that was able to generate primary standards of low vapor pressure analytes at the part-per-billion level, which served as the scientific foundation of the Defense Advanced Research Projects Agency (DARPA) Emissions Program test-bed. His basic research was extended into real-world applications with employment at ANSER where his primary responsibility was to lead the scientific and programmatic aspects of the DARPA Sensors for Immune Buildings Program, which sought to rapidly develop alternative detection technologies for use in future infrastructure protection. He also served as an advisor to the DARPA Immune Building (IB) program that culminated in the world’s first operational “smart building”, capable of autonomously detecting exposure, restoring building function (following an attack), and preserving forensic evidence. 

Following his time at ANSER, Dr. Boyd served as a Senior Scientist/Toxicologist at Johns Hopkins University Applied Physics Laboratory, where he spearheaded the development of a new predictive toxicology group focused on coupling mathematical models with in vitro pharmacodynamic responses. 

At WVU, Dr. Boyd has been very successful in using fundamental thermodynamic principles to deconstruct the basic mechanisms of survival and death by monitoring exposure(s) from the point of view of the biological system under stress. More specifically, Dr. Boyd is working toward an understanding of how humans interpret (from cellular mechanisms to physiological integration) the milieu of mixed environmental signals (ranging from chemical exposures to mental/physical stress) received each day. This complex area of research necessitates that the hypotheses be simple and straightforward (e.g. Bliss Independence applies to the integration of kinase responses), and requires that the experimental samples appropriately match the question at hand. Dr. Boyd has been fortunate to be able to work with multiple hierarchal levels of biological samples that include mammalian cell culture, animal models and human subjects. The applications of his research are vast, and range from toxicity screening to medical biomarkers and stress-related disease etiology. 

Teaching Fields

Biochemistry, Toxicology

Courses Offered

Publications

Han AA, Currie HN, Loos MS, Vrana JA, Fabyanic EB, Prediger MS, Boyd JW. Spatiotemporal Phosphoprotein Distribution and Associated Cytokine Response of a Traumatic Injury. Cytokine 79, 12-22. 2016.

Han AA, Boyd J. Chapter 17: Deguelin and its Role in Chronic Disease. In Drug Discovery from Mother Nature. Eds. S. Gupta, S. Prasad, B. Aggarwal. Springer International Publishing Switzerland. 2016.

Shamitko-Klingensmith N, Boyd J, Legleiter J. Microtubule Modification Influences Cellular Response to Amyloid-β1-42 Exposure. AIMS Biophysics 3, 261-285. 2016.

Han AA, Vrana JA, Mitchell C, Boyd JW. Identification of biomarkers related to Perceived Stress Scale-10 and the evaluation of survey components. Medical Genomics and Biomarkers 2, 003. 2015. 

Vrana JA, Currie (Williams) HN, Han AA, Boyd JW. Forecasting cell death dose-response from early signal transduction responses in vitro. Toxicological Sciences 140, 338-51. 2014. Selected as a Key Scientific Article contributing to biomedical research excellence by Global Medical Discovery.

Currie (Williams) HN, Vrana JA, Han AA, Scardoni G, Boggs N, Boyd JW. An approach to investigate intracellular protein network responses. Chemical Research in Toxicology 27, 17-26. 2014.

Currie (Williams) HN, Loos MS, Dragan K, Vrana JA, Boyd JW. Spatial cytokine distribution following traumatic injury. Cytokine 66, 112-118. 2014.

Vrana JA, Boggs NT, Currie (Williams) HN, Boyd JW. Amelioration of an undesired action of deguelin. Toxicon 74, 83-91. 2013.

Boyd JW, Vrana JA, Williams HN. In Vitro Approach to Predict Post-translational Phosphorylation Response to Mixtures. Toxicology 313 (2-3), 113-121. 2013.

Boyd JW, Saksena A, Patrone JB, Williams HN, Boggs NT, Le HT, Theodore ML. “Exploring the boundaries of additivity: mixtures of NADH-quinone oxidoreductase (complex I) inhibitors”. CHEM Res Tox 24 (8), 1242-1250. 2011.

McDaniel LN, Romero NA, Boyd JW, Coimbatore G, Cobb GP. “Capillary Column Gas Chromatographic-Mass Spectrometric Determination of the Organophosphate Nerve Agent Surrogate Dimethyl Methylphosphonate in Gaseous Phase”. Talanta, 81, 1568-71. 2010.

Boyd JW, Eckman CK, Romero NA, Ramkumar SS, Cox SB, Cobb GP. “The use of a thermogravimetric analyzer for the generation of primary analytical vapor standards of organophosphate pesticides”. Analytica Chimica Acta, 558, 35-41. 2006.

Boyd JW, Cobb GP, Southard GE, Murray GM. “Development of molecularly imprinted polymer sensors for chemical warfare agents”. Johns Hopkins APL Technical Digest, Volume 25, Number 1. 2004.

Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd, R. Neubig, and W. Xie. John Wiley & Sons Limited, Hoboken, NJ. Expected publication in 2016.

Haddad S, Tardif R, Boyd J and Krishnan K. Chapter 4: Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures. In Quantitative Modeling in Toxicology. Eds. K. Krishnan and M.E. Andersen. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-0-470-99809-0. 2010.

Krishnan K, Boyd J. Chapter 10: Toxicology of Chemical Mixtures. In General and Applied Toxicology, 3rd Edition. Ed. B. Ballantyne. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-0-470-72327-2. 2009.

Krishnan K, Isukapalli S, Boyd J. Chapter 9: Evaluation of Toxicological Interactions for the Dose-Response Assessment of Chemical Mixtures. In General and Applied Toxicology, 3rd Edition. Ed. B. Ballantyne. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-0-470-72327-2. 2009.

Coimbatore G, Cobb GP, Boyd JW, Marsland EJ, Presley SM. Sensing Biological and Chemical Threat Agents. In Advances in Biological and Chemical Terrorism Countermeasures. Eds. P.N. Smith, G.P. Austin, S.M. Presley, R.J. Kendall. CRC Press Boca Raton, FL. ISBN: 978-1-420-07654-7. pp 159-178. 2008. 

Website

http://boyd.chemistry.wvu.edu/